Endothelins reverse cytochalasin B-induced stellation of cultured astrocytes.
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چکیده
منابع مشابه
Hypoxia reverses dibutyryl-cAMP-induced stellation of cultured astrocytes via activation of the endothelin system.
Hypoxic damage to the central nervous system triggers morphological and functional responses in astrocytes (AC). When isolated from the cerebral microenvironment and placed in cell culture, hypoxia promotes astrocytic alterations indicative of dedifferentiation. To investigate the effect of hypoxia on AC morphology, we performed studies on cultured AC pretreated with dibutyrylcAMP. These treate...
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The cytochalasins are a new group of compounds which have been recently isolated from moulds. Some of their properties are of interest in the study of cytoplasmic and nuclear division since they have been shown to inhibit motility, produce nuclear extrusion and prevent cytoplasmic cleavage with the production of multinucleated cells. The present study is a report of the effects of cytochalasin ...
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We have recently found that L-glutamate suppresses morphological changes of astrocytes induced by amyloid beta protein, adenosine 3',5'-cyclic monophosphate or phorbol ester in culture. To test the possibility that L-glutamate affects organization of the cytoskeleton, we investigated its effect on morphological changes induced by disruption of actin filaments with cytochalasin B. Cultured rat c...
متن کاملCytochalasin B
Cytochalasin B competitively inhibits the transport of uridine and thymidine by Novikoff rat hepatoma cells growing in suspension culture with apparent K(i)'s of 2 and 6 microM, respectively, but has no effect on the intracellular phosphorylation of the nucleosides. Choline transport is not affected by cytochalasin B. Results from pulse-chase experiments indicate that cytochalasin B has no dire...
متن کاملCytochalasin B
Cytochalasin B, a mold metabolite, has been shown to inhibit cytokinesis and motility (3), morphogenie development (18), endocytosis (5), and the transport of sugars (8-10, 12). I t has also been demonstrated that this drug inhibits the stimuatcd elaboration of extracellular substances from glands-the release of thyroxine from the thyroid gland after stimulation by thyroid-stimulating hormone (...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1993
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)51889-3